Ratlarda Endojen ve Eksojen Hiperterminin Sebep Olduğu Nöronal Beyin Hasarı

• DOI: 10.4274/tnd.53244
• Publication Date: 2012-04-09T11:07:16Z
• Authors: Mustafa Aydın; Fatih Mehmet Kışlal; Mustafa Demirol; Feyza İnceköy Girgin; Nimet Kabakuş; Mesut Koçak
• Keywords: 0301 basic medicine; 03 medical and health sciences

Objective: Hyperthermia may induce pathologic alterations within body systems and organs including brain.In this study, neuronal effects of endogenous exogenous hyperthermia (41 °C) were studied in rats. Ma te ri al Met hod:The was induced by lipopolysaccharide the an (electric) heater.Possible damage evaluated examining healthy, apoptotic necrotic cells, heat shock proteins (HSP 27, HSP 70) cerebral cortex, cerebellum hypothalamus.Re sults: At cellular level, when all tissues are taken into account; (i) a significant increase cells observed both groups (p<0.05),(ii) while did not affect process significantly, led to apoptosis (p<0.05),whereas (iii) 70 levels increased (p<0.05) group, but they decreased group (p<0.05).No statistically change 27 (p>0.05). Dis cus si on:The neural tissue brain can show different degree response hyperthermia.But we conclude that is more harmful central nervous system than hyperthermia.(