Parameters of Calcium Metabolism Fluctuated during Initiation or Changing of Antipsychotic Drugs

• DOI: 10.4306/pi.2016.13.1.89
• Publication Date: 2016-01-04T08:08:52Z
• Authors: Dragan R. Milovan...; Marijana Stanojev...; Snezana Zivancevi...; Milovan Matovic; Slavica Djukic De...; Slobodan M. Jankovic; Dragan Ravanic; Milan Petronijevic; Dragana Ignjatovi...; Violeta Mladenovic; Mirjana Jovanovic; Sandra Nikolic La...; Marina Pajovic; Danijela Djokovic; Dusan Petrovic; Vladimir Janjic
• Keywords: Bone remodeling

Objective Serum parameters of calcium homeostasis were measured based on previously published evidence linking osteoporotic fractures and/or bone/mineral loss with antipsychotics. Methods Prospective, four-week, time-series trial was conducted and study population consisted patients both genders, aged 35-85 years, admitted within the routine practice, acute psychotic symptoms, to whom an antipsychotic drug either introduced or substituted. Serial measurements serum calcium, phosphorous, magnesium, 25(OH)D, parathyroid hormone, calcitonin, osteocalcin C-telopeptide made from patient venous blood samples. Results Calcium concentrations significantly decreased baseline fourth week (2.42±0.12 vs. 2.33±0.16 mmol/L, p=0.022, n=25). The mean all calcemia changes -2.6±5.7% (-24.1 7.7) more decreases than increases (78 49, p=0.010) patents having negative sum (n=28) positive ones (n=10) (p=0.004). There simultaneous falls magnesium (63/15 23/26, p<0.001; OR=4.75, 95% CI 2.14-10.51), phosphorous (45/33 9/40, 6.06, 2.59-14.20) 25(OH)D (57/21 13/35, 7.31, 3.25-16.42), respectively. Calcemia positively correlated magnesemia, phosphatemia values. Parathyroid hormone showed only subtle oscillations their absolute baseline; calcitonin did not change. Adjustment final trend (depletion/accumulation) for relevant risk factors, generally, change results. Conclusion In disorders several risks bone metabolism disturbances treatment associated decrease in levels ions. Keywords: Antipsychotic agents, Bone bones, Calcium, Minerals, Blood chemical analysis