Nephroprotective effect of methanol extract of Moringa oleifera leaves on acute kidney injury induced by ischemia-reperfusion in rats

• DOI: 10.4314/ahs.v20i3.44
• Publication Date: 2020-10-09T11:17:55Z
• Authors: Akinleye Stephen ...; Olusegun Oduwole; Fadeyemi Joseph A...; Folusho Bolawaye ...
• Keywords: Moringa; Malondialdehyde

Background: Moringa oleifera is known to exhibit protection against oxidative damage due its rich content of compounds with antioxidant activity. This study investigated the protective effect methanol extract (MO) in a rat model renal ischemia-reperfusion (IR) injury.
 Methods: Forty two wistar rats were randomly assigned six groups seven each, as follows: A, control group; B, sham-operated C, IR D, + low dose (200 mg/kg) MO; E, high (400 MO and F, Vitamin C mg/kg). Unilateral ischaemia was induced by occluding left artery for 45 minutes followed rep- erfusion up 24 hours.
 Results: significantly (p<0.05) ameliorated IR-induced increases malondialdehyde (MDA), protein carbon- yls (PC) advanced oxidation products (AOPP), while also decreasing serum BUN Creatinine levels. More- over, caused reductions NO H2O2 levels, increasing GPx GST activities. Histopathology revealed marked improvement tissue alterations both doses MO.
 Conclusion: Overall, M. effectively attenuated deleterious effects via allevi- ation stress.
 Keywords: Oxidative stress; ischaemia-reperfusion; oleifera; kidneys; antioxidants.