Maternal inherited thrombophilia and recurrent pregnancy loss: a Tunisian study and review of the literature

• DOI: 10.4314/ahs.v23i4.52
• Publication Date: 2024-04-04T10:22:53Z
• Authors: Frikha Rim; Turki Fatma; Abdelmoula Nouha; Rebai Tarek
• Keywords: Adult; Abortion, Habitual; Tunisia; Pregnancy Complications, Hematologic; Pregnancy Outcome; Factor V; Articles; Polymerase Chain Reaction; Young Adult; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Risk Factors; Mutation; Humans; Thrombophilia; Female; Prothrombin

Background: Inherited thrombophilia, mainly the Factor V Leiden (FVL) and Prothrombin mutation (PTM) are most risk factors for venous thrombosis especially during pregnancy was strongly associated with recurrent loss (RPL), a devastating reproductive problem that affects more than 1% of couples who trying to conceive. The frequencies also correlation among these polymorphisms RPL have been reported controversially in various populations.Objectives: In this study we evaluated presence inherited thrombophilia amongst 35 Tunisian women 2 miscarriages, referred our genetic counseling.Methods: DNA extracted from peripheral blood samples PCR-RFLP performed molecular diagnosis ofmutation.Results: FVL PTM were detected 5.7 % 2.9% respectively; particular history early fetal andthrombotic events.Conclusion: This emphasizes importance testing FIIM RPL; context thrombotic events. Multi-center collaboration is necessary clarify real impact defects on outcome, ascertain effect then evaluate appropriate therapeutic approach.