Neuropharmacological effects of Nigerian honey in mice

• DOI: 10.4314/ajtcam.v8i3.65285
• Publication Date: 2011-11-24T07:22:13Z
• Authors: MA Akanmu; TA Olowookere; SA Atunwa; BO Ibrahim; OF Lamidi; PA Adams; BO Ajimuda; LE Adeyemo
• Keywords: Elevated plus maze

Honey is a natural sweet substance that bees produce by transforming flower nectar or other secretions of plants. It has widespread use in traditional medicine various parts the world. been reported to assist building entire central nervous system. The beneficial effects honey have attributed possible polyphenolic contents and some constituents. geographical locations sources plant nectars may contribute samples. Thus, we evaluated neuropharmacological six samples (10%, 20% 40%V/v, p.o.) from three Nigeria using following behavioral models: Novelty-induced behaviors (NIB), learning memory, pentobarbital-induced hypnosis, anxiolytic, anticonvulsant, analgesic antidepressant models mice. results showed significantly (p< 0.05) decreased locomotion rearing NIB amphetamine-induced locomotor activity when compared control group. Exploratory behavior was increased both holeboard elevated plus maze but had no significant effect on spatial working memory. sample Umudike hypnotic anticonvulsant effects. antinociceptive (hot plate tail flick tests) pain reaction time naloxone blocked these force swimming test only Idanre (ID) effect. In conclusion, inhibitory property, antinociceptive, effects, thus be used as nutraceutic. can also inferred are probably mediated through dopaminergic opioidergic systems.Key words: Honey, neuropharmacology, medicine, antidepressant, mice