Synthesis, characterization, and biological evaluation of zinc(II) complexes with benzohydrazide derivative and phosphine ligands

• DOI: 10.4314/bcse.v39i2.10
• Publication Date: 2024-11-29T12:38:11Z
• Authors: Nazk M. Aziz; Ahmad A. Irzoqi
• Keywords: Characterization; Derivative (finance)

New zinc(II) complexes of the mixed ligands were synthesized using a benzohydrazide derivative (L), yielded from reaction and isatin, in combination with (Phen) various phosphine co-ligands, including 1,10-phenanthroline (Phen), 1,2-bis(diphenylphosphino)ethane(dppe), 1,2-bis(diphenylphosphino) propane (dppp), triphenylphosphine (PPh3). Characterization methods included molar conductivity, atomic absorption, FTIR, 1H, 13C{1H},31P{1H}-NMR spectroscopy, confirming tetrahedral geometry around ligand N'-(2-oxoindolin-3-ylidene) (L) acting as bidentate chelating ligand. The thermogravimetric (TG) analysis papered [Zn(L)(Phen)]Cl2, [Zn(L)(PPh3)]Cl2, [Zn(L)(dppp)]Cl2 showed that each them has been decomposed three stages. vitro biological activities evaluated against four types bacteria, Staphylococcus aureus, Streptococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, along cancer human liver (Hep-G2) cell lines, revealing exhibited significant cytotoxicity. Notably, [Zn(L)(Phen)]Cl2 complex strongest inhibitory effect on cells, an IC50 31.12 ± 1.57 μM. Antibacterial tests indicated effectively inhibited also had limited efficacy Gram-negative bacteria. Structure-activity relationship studies highlighted choice significantly influences properties these complexes. KEY WORDS: Antibacterial, Anticancer, Benzohydrazide derivative, Mixed complexes, Phosphines, Spectroscopy Bull. Chem. Soc. Ethiop. 2025, 39(2), 313-326. DOI: https://dx.doi.org/10.4314/bcse.v39i2.10