Effect of <i>Phellodendron chinense</i> Schneid Extract on Chronic Bacterial Prostatitis Induced by Chlamydia in Rats

• DOI: 10.4314/tjpr.v15i3.11
• Publication Date: 2016-04-12T08:48:19Z
• Authors: Limei Sun; Li Zhou; Jing Tian; Shuyun Zheng
• Keywords: Phellodendron chinense Schneid, Bacterial prostatitis, Inflammatory factors, Morphometric analysis, Interstitial fibrosis, Prostate specific antigen, Prostate index; 3. Good health

Purpose: To explore the effects of Phellodendron chinense Schneid (PCS) extract on chlamydiainduced chronic bacterial prostatitis (CBP).Methods: Sixty 8-week-old male Sprague-Dawley rats were used in this study. Prostate index (PI) and prostate specific antigen (PSA) determined after 4 weeks oral administration PCS (80, 160 or 320 mg/kg) tetracycline (80 compared to PI PSA untreated with CBP healthy control (n = 10). Chronic inflammatory cell infiltrates, acinar changes, interstitial fibrosis evaluated by histopathological examination. In addition, pertinent factors, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), cyclooxygenase-2 (COX-2), prostaglandin E2 (PEG2), transforming growth factor β1 (TGF-β1), connective tissue (CTGF), measured tissues using ELISA kits.Results: High doses (160 significantly decreased relative model group (p &lt; 0.01). treatment also reduced infiltrates rats. TNF-α, IL-1β, COX-2, PEG2, TGF-β1, CTGF PCS-treated 0.01).Conclusion: has significant anti-inflammatory chlamydia-induced CBP.Keywords: Schneid, Bacterial prostatitis, Inflammatory Morphometric analysis, Interstitial fibrosis, antigen,