Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D

• DOI: 10.4318/tjg.2011.0217
• Publication Date: 2016-03-14T15:34:08Z
• Authors: Gulseren SEVEN; Senem Ceren KARAT...; S. Kenan KOSE; Mustafa YAKUT; Gokhan KABACAM; Murat TORUNER; Aylin OKCU HEPER; Michael VOELKER; Esra ERDEN; A. Mithat BOZDAYI; Ozden UZUNALIMOGLU; Hakan BOZKAYA; Cihan YURDAYDIN; Detlef SCHUPPAN
• Keywords: Liver disease

Liver biopsy to assess fibrosis is invasive and prone sampling error. While algorithms of serum markers predict stage have been described for chronic hepatitis C, these cannot be applied equally well B.We therefore determined 9 markers, liver biochemical tests ultrasound parameters in 109 consecutive adult patients with B D. All had compensated disease. Using the METAVIR score, advanced disease was defined as ≥F2, active inflammation grade ≥A2. A gold standard created considering splenomegaly and/or platelets <150,000 indicators irrespective histology. Area under receiver operating characteristics curves used assessment single odds ratio their combinations.Patients were older, lower albumin, higher gamma glutamyl transferase platelet. Levels 6 tissue inhibitor metalloproteinases-1, procollagen type III aminoterminal propeptide, matrix metalloproteinase-2, laminin, hyaluronan collagen IV correlated fibrosis. Markers useful prediction also predicted marked inflammation. standard, age, prothrombin time, albumin independent predictors ratio's 3.11, 4.18, 3.35 5.25, respectively. Their combined use an 228.8. Tissue metalloproteinases-1 powerful (Odds 8.65 8.38). revealed 28.6, when compared standard.In conclusion, D may two markers.