Thymoquinone Prevents Valproic Acid-Induced Nephrotoxicity in Rat Kidney

• DOI: 10.46239/ejbcs.1123892
• Publication Date: 2022-12-21T18:15:27Z
• Authors: Sebile AZİRAK; Deniz TAŞTEMİR KO...; Sedat BİLGİÇ; Meltem ÖZGÖÇMEN; Mehmet Kaya ÖZER
• Keywords: Thymoquinone; Nephrotoxicity; Valproic Acid; Blood urea nitrogen

Valproic acid (VA), widely used as an antiepileptic, causes structural and functional kidney disorders. Whether thymoquinone (TQ) has a beneficial effect on valproic (VA)-induced nephrotoxicity been investigated. Twenty-one male Spraque Dawley rats were grouped into control, VA, VA + TQ groups (n=7 for per group). (500 mg/kg/day) (50 applied to the orally 14 days. They euthanized 15th day of treatment. The cyclooxygenase 1 (COX-1) 2 (COX-2) gene expression levels, biochemical parameters, total antioxidant/oxidant statuses (TAS/TOS), oxidative stress index (OSI), histological immunohistochemical analysis performed evaluate toxicity. In group, COX-1 levels increased, while COX-2 decreased. While creatinine (Cr) blood urea nitrogen (BUN) production caspase-3 (CAS-3) NADPH oxidase-4 (NOX-4) increased in VA-treated they decreased group. Treatment with against administration TOS OSI increasing TAS. protects toxic effects VA.