Morphological and immunohistochemical prognostic criteria for small cell lung cancers

• DOI: 10.46879/ukroj.1.2024.32-43
• Publication Date: 2024-04-19T08:42:31Z
• Authors: I.I. Yakovtsova; V.I. Starikov; O.V. Yanchevskyi; I.V. Ivakhno; A.B. Abdullaieva; M.A. Mirzebasov
• Keywords: прогноз; epithelial-mesenchymal transformation; small cell lung cancer; prognosis; епітеліально-мезенхімальна трансформація; дрібноклітинний рак легень

Background. Despite the fact that a lot of information on molecular genetic changes in lung cancers has been accumulated, there is still knowledge gap regarding determination key factors oncogenesis and trigger cause metastasis progression small cell cancer (SCLC). The problem comprehensive assessment prognostic importance changes, range IHC markers are used for diagnosing prognosing SCLC, impact epithelial-mesenchymal transformation (EMT) processes risk development tumor process lethal outcome disease remains relevant. Purpose – to improve morphological criteria course SCLC based research clinical biological characteristics primary tumors with different behavior prognosis. Materials methods. material was autopsy data surgically removed hospitals Kharkiv. We formed two groups type (limited-stage (LSCLC) extensive-stage (ESCLC)) overall survival (OS) patients. studies were performed using following markers: CD56, CD117, Ki-67, pan-cytokeratin, E-cadherin, vimentin, N-cadherin, CD44. took into account EMT stage coexpression epithelial (pan-cytokeratin E-cadherin) mesenchymal (vimentin N-cadherin) markers. Results. have found poor should include: emergence vimentin expression cells, increased level presence 3+ (stages 3–5). High levels E-cadherin Ki-67 favorable criteria. Some such as features, histological study, CD44, neuroendocrine phenotype limited value. Conclusions. identified belonging or extensive process. recommended panel taking EMT.