The pioneer use of a modified PRGF–Endoret® technique for wound healing in a hemodialyzed diabetic patient in a terminal stage of renal disease

• DOI: 10.47162/rjme.62.2.12
• Publication Date: 2022-01-20T16:11:44Z
• Authors: Ioana Adela Raţiu; Cristian Adrian R...; ; Viorel Miclăuş; ; Adina Bianca Boşca; ; Rümeyza Turan Kaz...; ; Anne Marie Consta...; ; Gabriel Cristian ...; ; Alina Simona Şovrea
• Keywords: 0301 basic medicine; Original Paper; Plasma; Wound Healing; 03 medical and health sciences; 0302 clinical medicine; Platelet-Rich Plasma; Diabetes Mellitus; Humans; Intercellular Signaling Peptides and Proteins; Female; Aged

In the literature, this paper is the first to describe the use of plasma rich in growth factors (PRGF)-Endoret® in hemodialyzed diabetic patients, to promote the healing of after amputation wounds. The PRGF-Endoret® was primarily conceived to be used in maxillofacial surgery, oral implantology, etc., the innovation residing in the blood collection technique (quantity, moment of the week, rhythmicity), which was adapted to the specific conditions of the hemodialyzed patient. Moreover, in the initial phases, the two PRGF fractions were innovatively applied as single alternating layers on the wound surface. Only after the surface of the wound decreased, the two PRGF fractions were applied as overlapping layers. Nevertheless, the paper presents the optimal method to assess the clinical evolution of the wound. Histopathological examination of the biopsy performed during wound preparation for PRGF application brought additional, essential data for orienting the therapeutic approach. The exclusion of calciphylaxis, a disease with high mortality risk, encouraged the application of this method, and also demonstrated the microscopic features in hemodialyzed diabetic patients.