MiR-144 Regulates Hemoglobin Expression in Human Erythroid Cell Line

• DOI: 10.48048/wjst.2020.10712
• Publication Date: 2020-11-04T02:51:30Z
• Authors: Tipparat PENGLONG; Apisara SAENSUWANNA; Jitpanu KOCHAROENWAT; Wittawat BOORINTA...; Suppanut FUPONGSI...; Kanitta SRINOUN
• Keywords: Gene cluster

The regulation of globin gene expression is significantly important to understand the pathogenesis disorders. Recent findings have shown that microRNAs (miRNAs, miRs) play an role in expression. miR-144 erythroid lineage-specific miRNA, which its mediates NRF2 silencing and inhibits fetal hemoglobin However, roles other genes especially ɑ-globin cluster remain unknown. This study, thus, examined functional studies K562 human cell line. results revealed z-globin were silenced by overexpressed correlated with reduced KLF1- suspected target gene. By contrast, transfection inhibitor reversed effect miR-144. On hand, had no β-globin Our sustain previous overexpression correlates repressing 𝛄-globin Taken together, our suggest plays a key through mRNA adult embryonic possibly targeting KLF1