The external pallidum: think locally, act globally

• DOI: 10.48550/arxiv.2104.10795
• Publication Date: 2021-01-01
• Authors: Courtney, Connor D.; Pamukcu, Arin; Chan, C. Savio
• Keywords: 0301 basic medicine; 0303 health sciences; 03 medical and health sciences; Quantitative Biology - Neurons and Cognition; FOS: Biological sciences; Neurons and Cognition (q-bio.NC)

The globus pallidus (GPe) of the basal ganglia has been underappreciated for decades due to poor understanding of its cells and circuits. The advent of molecular tools has sparked a resurgence in interest in the GPe. Here, we review a recent flurry of publications that has unveiled the complexity of the molecular landscape and cellular composition within the GPe. These discoveries have revealed that GPe neurons display a number of circuit features that do not conform to the traditional views of the basal ganglia. Consistent with its broad interconnectivity across the brain, emerging evidence suggests that the GPe plays multifaceted roles in both motor and non-motor functions. Altogether, recent data highlight cellular and functional diversity within the GPe and prompt new proposals for computational rules of the basal ganglia.