Hyperpolarized Solution-State NMR Spectroscopy with Optically Polarized Crystals.

• DOI: 10.48550/arxiv.2108.06147
• Publication Date: 2022-02-03
• Authors: Eichhorn, Tim R.; Parker, Anna J.; Josten, Felix; Müller, Christoph; Scheuer, Jochen; Steiner, Jakob M.; Gierse, Martin; Handwerker, Jonas; Keim, Michael; Lucas, Sebastian; Qureshi, Mohammad...; Marshall, Alastair; Salhov, Alon; Quan, Yifan; Binder, Jan; Jahnke, Kay D.; Neumann, Philipp; Knecht, Stephan; Blanchard, John W.; Plenio, Martin B.; Jelezko, Fedor; Emsley, Lyndon; Vassiliou, Christ...; Hautle, Patrick; Schwartz, Ilai
• Keywords: Chemical Physics (physics.chem-ph); naphthalene; resolution; signals; FOS: Physical sciences; probe; 02 engineering and technology; spin polarization; 01 natural sciences; xenon; 0104 chemical sciences; triplet-state; Physics - Chemical Physics; dynamic nuclear-polarization; para-hydrogen; 0210 nano-technology; enhancement

8 pages, 4 figures<br/>Nuclear spin hyperpolarization provides a promising route to overcome the challenges imposed by the limited sensitivity of nuclear magnetic resonance. Here we demonstrate that dissolution of spin-polarized pentacene-doped naphthalene crystals enables transfer of polarization to target molecules via intermolecular cross relaxation at room temperature and moderate magnetic fields (1.45$\,$T). This makes it possible to exploit the high spin polarization of optically polarized crystals while mitigating the challenges of its transfer to external nuclei, particularly of the large distances and prohibitively weak coupling between source and target nuclei across solid-solid or solid-liquid interfaces. With this method, here we inject the highly polarized mixture into a benchtop NMR spectrometer and observe the polarization dynamics for target $^1$H nuclei. Although the spectra are radiation damped due to the high naphthalene magnetization, we describe a procedure to process the data in order to obtain more conventional NMR spectra, and extract the target nuclei polarization. With the entire process occurring on a timescale of one minute, we observe NMR signals enhanced by factors between -200 and -1730 at 1.45$\,$T for a range of small molecules.<br/>