Probing polarization response of monolayer cell cultures with photon entanglement

• DOI: 10.48550/arxiv.2401.10789
• Publication Date: 2024-01-01
• Authors: Lixin Zhang; Vira R. Besaga; Philipp Rühl; Chen Zou; Stefan H. Heinemann; Yong Wang; Frank Setzpfandt
• Keywords: Sample (material)

This study addresses the critical need for high signal-to-noise ratio in optical detection methods biological sample discrimination under low-photon-flux conditions to ensure accuracy without compromising integrity. We explore polarization-based probing, which often excels over intensity modulation when assessing a specimen's morphology. Leveraging non-classical light sources, our approach capitalizes on sub-Poissonian photon statistics and quantum correlation-based measurements. present novel, highly sensitive method probing single-layer cell cultures using entangled pairs. Our demonstrates capability monolayer analysis, distinguishing between two types of cells their host medium. The experimental results highlight method's sensitivity, showcasing its potential techniques, paving way advanced diagnostic methodologies.