Remote-Controlled Activation of the Release through Drug-Loaded Magnetic Electrospun Fibers

• DOI: 10.48550/arxiv.2406.01410
• Publication Date: 2024-06-03
• Authors: Richard Ziegler; Shaista Ilyas; Sanjay Mathur; Gerardo F. Goya; Jesús Antonio Fue...
• Keywords: Electrospinning

The integration of magnetic nanoparticles within fibrillar structures represents an interesting avenue for the remotely controlled release therapeutic agents. This work presents a novel drug platform based on electrospun fibers (EMFs) combining drugs, (MNPs) and mesoporous silica (MSNs) delivery via alternating fields (AMF). was demonstrated to be versatile effective hydrophilic ketorolac (KET) hydrophobic curcumin (CUR) encapsulation major response observed AMF-triggered reached using drug-loaded MSNs fibers, providing fine control over patterns. EMFs exhibited excellent inductive heating capabilities, showing temperature increase up 8 {\deg}C 5 min AMF pulse. system is shown promising applications like transdermal pain management, oncological delivery, tissue engineering, wound healing, enabling precise in both spatial temporal dimensions. findings this study offer valuable insights into development next generation smart systems, multifunctional materials that can regulated potentially revolutionize field nanomedicine.