Approaching the Physical Limits of Specific Absorption Rate in Hyperthermia Applications

• DOI: 10.48550/arxiv.2408.10377
• Publication Date: 2024-08-19
• Authors: Subas Scheibler; H. Wei; Justin Ackers; Santiago Helbig; Sabri Koraltan; Reshma Peremadath...; Martin Krupinski; Matthias Graeser; Dieter Suess; Inge K. Herrmann; Hans J. Hug
• Keywords: Specific absorption rate

Magnetic nanoparticle-based hyperthermia has emerged as a promising therapeutic modality for treating malignant solid tumors that exhibit resistance to conventional cancer treatments, including chemotherapy and radiation. Despite the clinical approval of superparamagnetic iron oxide nanoparticles (SPIONs) adjunct treatment recurrent glioblastoma, their potential is undercut by chemical synthesis-inherent limitations such low saturation magnetization, characteristics, wide nanoparticle size distribution. Here, we introduce an micromagnetic modelling-based SAF-MDP design with in-plane optimized through specific uniaxial anisotropy adjustments avert spin-flop phenomenon eliminate hysteresis-free hard-axis magnetization loops, paired mechanofluidic modeling approach assess alignment applied alternating magnetic field (AMF). Force Microscopy characterization provides unprecedented insights into particle switching behaviour on single scale. This comprehensive strategy spanning micromagnetics advanced enables particles heating efficiencies theoretical maximum, dictated utilized materials limited solely biologically acceptable frequencies amplitudes oscillating field. Our work not only addresses encountered previous methodologies but also sets stage development designs techniques. opens new avenue hyperthermia-based therapy, delineated boundaries physical laws biological safety standards.