Role of Substance P in Regulating Micro-Milieu of Inflammation in Alopecia Areata

• DOI: 10.5021/ad.21.161
• Publication Date: 2022-08-01T04:05:55Z
• Authors: Changhyeon Kim; Jung-Min Shin; Doyeon Kim; Sanghyun Park; Dongkyun Hong; Kyung Eun Jung; Chang-Deok Kim; Young-Joon Seo; Young Lee
• Keywords: Pathogenesis; Tachykinin receptor 1; Epidermis (zoology)

Alopecia areata (AA) is an autoimmune disease characterized by chronic inflammation, the pathogenesis of which unknown. Stress believed to play a role; however, evidence remains insufficient. A recent study showed that substance P (SP) damaged hair follicles causing neurogenic activating perifollicular mast cells, and inducing keratinocyte apoptosis.We aimed at studying role SP in AA pathogenesis. We investigated levels lesional scalp tissues serum. also studied effect on inflammatory response growth outer root sheath (ORS) cells.We compared serum 58 patients 28 healthy subjects. Then, we checked expression receptor, neurokinin-1 receptor (NK-1R) scalps controls using immunohistochemical staining. Finally, analyzed mRNA cytokines growth-related factors ORS cells.SP NK-1R were markedly higher interfollicular epidermis lesions patients. However, there was no statistically significant difference between patients, regardless type alopecia. significantly increased decreased but results not dramatic.SP triggered localized micro-inflammation follicles, provoked response, inhibited growth, thereby confirming pathogenic AA.