Causes of erythrocytosis and its impact as a risk factor for thrombosis according to etiology: experience in a referral center in Mexico City

• DOI: 10.5045/br.2021.2021111
• Publication Date: 2021-08-31T00:45:22Z
• Authors: Antonio Olivas-Ma...; Eduardo Corona-Ro...; Adrián Nuñez-Zuno; Olga Barrales-Ben...; Daniel Montante-M...; Jesús Delgado-de ...; Diana León-Aguilar; Hilda Elizeth Her...; Elena Tuna-Aguilar
• Keywords: Etiology

Thrombotic events are well documented in primary erythrocytosis, but it is uncertain if secondary etiologies increase the risk of thrombosis. This study aimed to determine causes erythrocytosis and identify its impact as a factor for thrombosis.Data were obtained from patients with between 2000 2017 at referral hospital Mexico City. Erythrocytosis was defined according 2016 WHO classification. Time thrombosis, major bleeding, or death compared among groups by etiology using Cox regression model, adjusting cardiovascular factors.In total, 330 studied. The main obstructive sleep apnea (OSA) 29%, polycythemia vera (PV) 18%, chronic lung disease (CLD) 9.4% patients. incidence rate thrombosis significantly higher PV CLD than that OSA (incidence rates 4.51 6.24 vs. 1.46 cases per 100 person-years, P=0.009), mortality (mortality 2.72 2.43 0.17 P =0.003).The comparable PV. Further larger-scale studies needed confirm these findings evaluate benefits preventive management COPD similar