Prevalence and risk factors of liver fibrosis in patients with metabolic-associated fatty liver disease undergoing bariatric surgery

• DOI: 10.5114/ceh.2024.145701
• Publication Date: 2024-12-12T10:27:17Z
• Authors: Amr Elsayed; Alshymaa Hassnine; Mariana F. Gayyed; Fatma Saied; Mohamed A. Abdelz...; Yasser Fouad; Alaa M. Mostafa; Mohamed Khalaf
• Keywords: noninvasive scores; bariatric surgery; R; Medicine; mafld; liver fibrosis

Liver fibrosis affects progression of fatty liver. Epidemiological data about in overweight/obese Egyptian patients undergoing bariatric surgery are limited. We aimed to assess hepatic steatosis and with metabolic associated liver disease (MAFLD) before via noninvasive tools biopsy. A cross-sectional study MAFLD the Hepatogastroenterology Hospital was performed. For all recruited cases, history taken clinical examination, laboratory testing, intra-operative laparoscopic biopsies histopathological evaluation were conducted. Fibrosis-4 (FIB-4), NAFLD Fibrosis Score (NFS), AST platelet ratio (APRI) calculated. The final number significant 85; these, 24/85 (28.2%) met criteria (F2), 11/85 (12.9%) had advanced (F3-F4), 50/85 (58.8%) no (F0-F1). significantly higher elderly, smokers, those diabetes, hypertension, or chronic hepatitis C virus (HCV) infection. Degree positively correlated body mass index (BMI), waist-hip (WHR), alanine aminotransferase (ALT), aspartate (AST), triglyceride, cholesterol, serum uric acid, fasting blood sugar (FBS), HbA1c levels, negatively level. Regression analysis indicated that smoking, elevated BMI, presence diabetes decreased level acid predictors fibrosis. Non-invasive models, such as FIB-4, NFS, APRI provided greater accuracy for predicting Significant (F ≥ 2) detected > 1/3 surgery. Presence high WHR, age, low risk factors 2). Noninvasive can be used identify patients.