The comparison of SARS-CoV-2 antibody levels in medical personnel induced by different types of vaccines compared to the natural infection

• DOI: 10.5114/ceji.2023.125239
• Publication Date: 2023-03-02T07:44:30Z
• Authors: Ljiljana Božić; Darija Knežević; Maja Travar; Nataša Miljuš; Miroslav Petković; Jela Aćimović; Jelena Djaković D...; Miloš P. Stojiljk...; Dejan Bokonjić; Ranko Škrbić
• Keywords: Antibody response

During the last two and a half years, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread around world. Most of SARS-CoV-2 vaccines are designed to produce anti-SARS-CoV-2 immunoglobulin G (IgG) against viral S-glycoprotein. The aim this study was measure anti-S antibody titres among medical personnel who had been fully vaccinated with different types vaccines, compare them those were COVID-19 convalescents.In serum collected from 261 healthcare workers, whom 227 vaccinated, while 34 recovered participants not immunised. Serum samples 21 days after first dose 60 180 second tested commercial ELISA kit.The highest level (12 AU/ml) measured in Pfizer-BioNTech group, followed by Sinopharm (9.3 AU/ml), Sputnik V (5.9 Sinovac (4.6 Oxford/Astra- Zeneca vaccine (2.5 (90 dose). seropositivity rate for mRNA 88.5%, vector 86.2% inactivated 71.4%. When comparing these levels convalescents, higher found (5.76 AU/ml vs 7.06 but difference significant (p = 0.08).Individuals seroconversion compared group or convalescents.