Apparent diffusion coefficient and T2* mapping on 3T MRI in normal and degenerative lumbar intervertebral discs

• DOI: 10.5114/pjr.2023.128882
• Publication Date: 2023-06-23T12:57:42Z
• Authors: Reetika Kapoor; Varsha Purushotta...; Divyajat Kumar; Shashank Raina; Akhil Revikumar; Karthik Mohanan
• Keywords: Original Paper; modified Pfirrmann grading; ADC; T2* mapping; DWI; lumbar degenerative disc

To assess the utility of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps and T2* mapping in quantitative analysis nucleus pulposus (NP) annulus fibrosus (AF) lumbar intervertebral discs its correlation modified Pfirrmann grading (MPG) for degenerative disc disease (LDDD).One hundred subjects (20-74 years age) underwent T2-weighted, DWI ADC magnetic resonance imaging. MPG was applied to L3-L4, L4-L5, L5-S1 discs, values NP AF were calculated mid-sagittal plane by segmenting each into 5 regions interest (ROI) (NP-3, AF-2). Mean values, their correlation, cut-offs among different grades at ROIs across levels.Out total 300 analysed; 68 normal (grade I) 232 degenerated II VIII) based on MPG. NP, AF, entire significantly lower than discs. There significant (p < 0.001) negative between cut-off statistically grades, area under curve (AUC) moderate high accuracy range (0.8 > 0.9) assessing degree LDDD.T2* value-based grade scales are highly accurate evaluating degeneration a objectivity comparison visual assessment-based Reduced could serve as markers early LDDD.