Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats

• DOI: 10.5115/acb.2018.51.1.41
• Publication Date: 2018-04-03T08:53:53Z
• Authors: Adekomi Damilare ...; Adegoke Adebiyi A...; Tijani Ahmad Adek...; Olaniyan Olayinka...; Alabi Mutiyat Ola...; Ijomone Kafilat O...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Original Article; 3. Good health

In the developed and developing world, opioid consumption in combination with alcohol has become one of substances abused. this experiment, we examined effects alcohol, morphine, morphine+alcohol on cognitive functions neuroinflammatory responses medial prefrontal cortex (mPFC) juvenile male rats. Alcohol (1.0 ml 15% v/v ethanol twice daily, subcutaneously, 7 hours apart), morphine (0.5 ml/kg 0.4 mg/kg chlorate co-treatment chlorate+1.0 apart) were administered for 21 days. Treatment significantly impairs cognition Morris water maze, passive avoidance, novel object recognition tests, furthermore, treatment increased quantitative count astrocytic cells also conferred marked neuronal cell death mPFC, which studied by glial fibrillary acidic protein immunochemistry astrocytes Cresyl violet Nissl's substance distribution neurons respectively. These results suggest that may trigger deficits brain.