Biological effects caused by the pharmaceuticals losartan and diclofenac, and their mixture on marine organisms

• DOI: 10.5132/eec.2022.01.11
• Publication Date: 2022-08-12T22:56:23Z
• Authors: Juliana Andrade d...; Fabio Hermes Pusc...; Andressa Dos Sant...; Maysa Ueda de Car...; Rafaela Amaral Go...; Denis Moledo de S...; Camilo Dias Seabr...; Luciane Alves Mar...
• Keywords: Diclofenac; Chronic toxicity; Artemia salina

Studies show that pharmaceuticals are being taken to the oceans causing contamination and toxicity aquatic organisms. The present study evaluated survival rate of microcrustaceans Artemia salina abnormal embryo larval development sea urchin Echinometra lucunter, after exposure drug Losartan, an antihypertensive drug, Diclofenac, a non-steroidal antiinflammatory (NSAID), in addition its mixture among compounds. Acute tests were carried out using A. chronic embryos E. lucunter. Organisms exposed isolated at different concentrations: 1.56 mg.L-1; 3.12 6.25 12.5 25 50 mg.L-1 100 mg.L-1, their 0.78 6.25mg.L-1; mg.L-1. result obtained acute test did not salina. Chronic with losartan embryos, contrast, diclofenac showed NOEC = LOEC IC50 62.15 diclofenac, NOEC= LOEC= possible IC50. Our results suggest two studied might decrease toxicity, since higher lucunter when it was than mixed losartan. However, there is need for further ecotoxicological studies clarify pathways these non-target