Core biopsy diagnosis of alk positive inflammatory myofibroblastic tumor of lung: an interesting case

• DOI: 10.5146/tjpath.2018.01446
• Publication Date: 2018-12-04T14:07:01Z
• Authors: Ritesh Sachdev; Ishani Mohapatra; Shalini Goel; Kulbir Ahlawat; Neelam Sharma
• Keywords: Anaplasia; Lung tumor; Neoplasm; Immunostaining

Inflammatory myofibroblastic tumor (IMT) of lung is a rare tumor, accounting for ~0.7% all tumors with varied clinical and radiological presentations.The origin this unknown but some studies suggest that it might be true neoplasm as mutations on chromosome 2p23 anaplastic lymphoma kinase (ALK) have been found to related tumor.The morphology IMT quite vague the histopathological diagnosis predominantly given excision specimens; in fact, only 6.3% cases are diagnosed based analysis biopsy specimens alone.We illustrate case young male core biopsy, where presented large metastases multiple sites was hence unresectable.Post 3 months treatment Crizotinib, there significant reduction size.Another interesting finding ALK immunostain, which helped immensely diagnosis, appreciated better Ventana platform rather than Dako platform.