Low serum free triiodothyronine levels are associated with the presence and severity of coronary artery disease in the euthyroid patients: an observational study

• DOI: 10.5152/akd.2012.187
• Publication Date: 2012-08-08T16:31:06Z
• Authors: Faruk Ertas; Hasan Kaya; Mehmet Serdar Soy...
• Keywords: Thyroid-stimulating hormone

The aim of this study is to investigate the relationship between serum thyroid hormone levels that are within normal range and presence severity coronary artery disease (CAD) in patients referred for angiography.In observational study, we enrolled 119 consecutive (77 men, mean age 60.7±13.8 years) who underwent angiography. Blood samples were tested stimulating (TSH), free triiodothyronine (FT3) thyroxine (FT4) concentrations. Additionally, risk factors, clinical characteristics angiographic results obtained. separated into two groups according Gensini score as those with mild or severe atherosclerosis. Statistical analysis was performed using Chi-square, Mann-Whitney U, correlation logistic regression tests, ROC analysis.FT3 significantly lower subjects CAD (4.0±0.7 vs. 4.6±0.6 pmol/L; p<0.001). Moreover, FT3 found atherosclerosis (3.9±0.7 4.5±0.6 Logistic demonstrated associated (OR =0.266, 95% CI: 0.097-0.731, p=0.01) (OR=0.238, CI:0.083-0.685, p=0.008) CAD. In analysis, a level ≤4.2 pmol/L predict 69% sensitivity 71% specificity (AUC:0.744, CI:0.653-0.834, p<0.001); 75% 67% (AUC:0.733, CI:0.642-0.824, p<0.001).FT3 inversely correlated concentrations independently predicted Thus, may be used indicator increased