Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women

• DOI: 10.5152/akd.2015.6016
• Publication Date: 2015-05-07T06:31:43Z
• Authors: Petar Avramovski; Maja Avramovska; Miroslav Lazarevski; Aleksandar Sikole
• Keywords: Lumbar Vertebrae; Middle Aged; Atherosclerosis; Sensitivity and Specificity; Severity of Illness Index; Postmenopause; 03 medical and health sciences; Absorptiometry, Photon; Cross-Sectional Studies; 0302 clinical medicine; ROC Curve; Bone Density; Surveys and Questionnaires; Humans; Female; Femur; Aorta; Biomarkers; Osteoporosis, Postmenopausal; Original Investigation; Aged

Osteoporosis and abdominal aortic calcification (AAC) are associated with increased morbidity mortality in postmenopausal women. The aim of this study was to determine the accuracy anterior-posterior (AP) dual-energy X-ray absorptiometry (DXA) compared that lateral lumbar radiography (LLR) detecting scoring AAC.In cross-sectional conducted 56 asymptomatic females aged 59.0 ± 9.3 years who never used medications treat osteoporosis before, we determined femoral neck spine bone mineral density (BMD) by AP DXA AAC LLR. We hypothesized subtracted BMD (BMDFN) from (BMDLS) presented as ΔBMD=BMDLS-BMDFN would have a diagnostic value vascular calcification.The mean BMDFN 0.744 0.184 g/cm(2), BMDLS 0.833 0.157 g/cm(2) (p<0.0001); ΔBMD 0.089 0.077 score 2.182 1.982. Bivariate Pearson's correlation analysis revealed significant positive between (r=0.449, p=0.0006); linear regression analysis, R(2)=0.2019, multiple βst=13.5244 (p<0.0001). found sensitivity 64.3% specificity 82.9% receiver operating characteristic [ROC; area under ROC curve (AUC=0.759)] prediction ΔBMD.This subtracting method provides useful tool for subclinical extensive women using simple, semiquantitative, accurate system minimal radiation exposure low cost.