Risk Factors for Bloodstream Infections Due to Acinetobacter spp.: A Prospective Case-Control Study

demography invasive procedure 610 Bacteremia bloodstream infection parenteral nutrition high risk patient 01 natural sciences Article Turkey (republic) 03 medical and health sciences 0302 clinical medicine 616 beta lactamase inhibitor antibiotic therapy antifungal agent controlled study human 0101 mathematics beta lactam antibiotic teicoplanin clinical article nonhuman treatment duration Acinetobacter disease association carbapenem derivative case control study Parenteral nutrition 3. Good health univariate analysis hospital patient multivariate analysis risk factor Teicoplanin hospitalization prospective study
DOI: 10.5152/kd.2015.21 Publication Date: 2015-12-16T07:11:58Z
ABSTRACT
Objective: The aim of this prospective case control study was to describe the risk factors for bacteremia due to Acinetobacter species among hospitalized patients. Methods: The study was conducted prospectively from July 2012 to January 2014, and one case group and two control groups were created. Case group comprising patients with Acinetobacter bacteremia and control group 1 comprising patients with bacteremia due to other agents and control group 2 comprising non-bacteremic patients were compared in terms of demographic characteristics, underlying diseases, invasive procedures, and antibiotic use. Results: The study group (n=23) and control groups (n=46) were compared with univariate analysis and significant risk factors for Acinetobacter bacteremia were as follows: total parenteral nutrition, chemotherapy, use of broad spectrum antibiotics including ß-lactam and ß-lactamase inhibitors, carbapenems, teicoplanin, and antifungals (p<0.05). The duration of hospitalization was longer in case group (p=0.005). In multivariate analysis, factors independently associated with an increased risk of Acinetobacter spp. bacteremia included total parenteral nutrition (odds ratio, OR 5.13; confidence interval 95%, CI 95%, 1.41-18.57; p=0.013), use of a ß-lactam/ß-lactamase inhibitor (OR 7.67; CI 95% 1.67- 35.25; p=0.009), and use of teicoplanin (OR 4.11; CI 95% 1.09- 15.46; p=0.036). Conclusions: The definition of risk factors for Acinetobacter spp. bacteremia may help with the management of patients and infection control precautions by early prediction of the infection. © 2015, AVES Ibrahim Kara. All rights reserved.
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