Assessment of Serum Dynamic Thiol/Disulfide Homeostasis and Oxidative/Nitrosative Stress in Patients with Crohn’s Disease

• DOI: 10.5152/tjg.2024.23519
• Publication Date: 2024-11-27T11:43:48Z
• Authors: Ancel Aysun Bağdaş; Sezgin Barutçu; ; Ahmet Saracaloğlu; ; Abdullah Tuncay D...
• Keywords: Thiol; Homeostasis; S-Nitrosylation

Crohn's disease (CD) is a major subtype of chronic relapsing inflammatory gastrointestinal disorders. In this study, we assessed the possible contributions serum oxidative/nitrosative stress and dynamic thiol/disulfide homeostasis to CD pathogenesis. Patients with active (A-CD) at onset (n = 38), patients in remission (R-CD) healthy controls 38) were prospectively included study. Serum parameters as well total thiol native levels analyzed. We observed significant augmentation nitric oxide (NO) both A-CD R-CD compared controls. detected marked reductions 3-nitrotyrosine patient groups. Glutathione, glutathione peroxidase, myeloperoxidase be significantly lower groups (P < .001). group, .001) .01) lower, disulfide higher than those control group .01), while thiol/total ratio was reduced disulfide/total disulfide/native ratios elevated. Remarkably, no change found group. Our results showed increased NO decreased antioxidant enzymes, particularly during phase CD. Determination could help differentiate between phases disease. Thiol/ can used biomarkers for A-CD.