Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence

• DOI: 10.5173/ceju.2020.0168.r1
• Publication Date: 2021-01-13T16:52:40Z
• Authors: Fabio Zattoni; Iliana Bednarova; Alessandro Morlacco; Giovanni Motterle; P. Beltrami; Fabrizio Moro; R. Jeffrey Karnes
• Keywords: Urinary diversion; Concomitant

Transitional cell carcinoma recurrence within an intestinal urinary diversion (TCCUD) after radical cystectomy (RC) is a rare condition with unknown origin, prognosis and treatment. The aim of this study was to describe treatment options oncologic outcomes understudied site in multi-institutional case series.TCCUD relapse cases RC were investigated retrospective, study. Surgical approach adjuvant chemotherapy discussed. Early late complications described according the Clavien-Dindo classification. Kaplan-Meier method used assess progression-free cancer-specific survival.A total 19 patients selected. most common presentation gross hematuria. median interval between TCCUD 51.2 months. Fifteen (78.9%) underwent surgical excision, two concomitant nephroureterectomy. In 12 (63.1%) uretero-ileal anastomosis. Tumor invading muscularis 10 (52.6%) cases. occurred 7/15 (46.6%) patients, these Grade III. Four (21.0%) (10.5%) both radiation therapy. During follow-up 15 presented other sites recurrence, lymph nodes liver (15.7%) being localizations. Recurrence free overall survival rates 36.8% 15.8%, 56.5% 24.2%, respectively at 18 months.Most have invasive disease substantial percentage experience upper tract cancer during their course. often herald advanced systemic progression, poor rates.