Light-coupled cryogenic probes to detect low-micromolar samples and allow for an automated NMR platform

• DOI: 10.5194/mr-5-61-2024
• Publication Date: 2024-05-15T11:37:46Z
• Authors: Wolf Wüster; Pit Gebbers; Alois Renn; Matthias Bütikofer; Sophie Rüdiger; Roland P. Riek; Felix Torres
• Keywords: Electricity and magnetism; QC501-766; Hyperpolarization; Photo-CIDNP; 530: Physik; Nuclear magnetic resonance (NMR)

Recent advances in NMR fragment screening use sample illumination to boost sensitivity, reduce measurement time a few seconds, and concentration micromolars. Nevertheless, the absence of fully automated solution measure several hundreds samples with photoinduced hyperpolarization limits large-scale applicability method. We present setup couple an optical fiber cryogenic probe using flow-cell accessory port. This is compatible commercially available autosamplers, enabling per day.