Role of antioxidants in reducing oxidative stress and seizure frequency in drug-resistant epileptic patients

• DOI: 10.52225/narra.v4i2.790
• Publication Date: 2024-08-06T14:22:40Z
• Authors: Jufitriani Ismy; Amanda Soebadi; Irawan Mangunatmadja; Merci Monica; Teny T. Sari; Klara Yuliarti
• Keywords: Epileptic seizure

Drug-resistant epilepsy presents significant challenges in treating epileptic patients, leading to recurrent seizures and necessitating the use of polypharmacy with anti-epileptic drugs. Both these conditions contribute increased oxidative stress, which is detrimental brain. The aim this study was determine role vitamins C E reducing stress seizure frequency drug-resistant patients. This a double-blinded, randomized clinical trial placebo, parallel design, block randomization. subjects were patients aged 1-18 years who received routine treatment. Randomization performed on 100 divided into treatment or placebo groups. combination vitamin (100 mg/day) (200 IU/day for those <5 400 ≥5 years) eight weeks. Malondialdehyde (MDA) levels measured prior after intervention. A total 42 46 followed till end intervention groups, respectively. Our data indicated that MDA not significantly different between groups (0.901 vs 0.890 mmol/mL,