Bioenhancer Herbs: Natural Agents for Optimizing Drug Efficacy and Bioavailability

• DOI: 10.52228/jrub.2024-37-2-9
• Publication Date: 2024-12-30T15:48:17Z
• Authors: Pratik Singh
• Keywords: Piperine

This review article explores the role of herbal bioenhancers in improving drug bioavailability, a crucial factor for therapeutic efficacy. Drug bioavailability is often limited by poor solubility, low membrane permeability, and metabolic degradation. Traditional modern approaches have developed various methods to address these barriers, including use bioenhancers, which naturally augment absorption effects drugs without producing pharmacological themselves. Key include piperine, curcumin, ginger, act inhibiting enzymes like cytochrome P450 efflux proteins such as P-glycoprotein, thereby increasing concentration at target sites. reviews bioenhancer mechanisms, highlighting how specific compounds turmeric, aloe vera can enhance used treating chronic conditions tuberculosis, cancer, infections. The benefits extend beyond enhanced efficacy reduced dosages, minimized side effects, lower costs, making them an attractive adjunct formulations. However, challenges remain scaling up production ensuring regulatory compliance, especially context novel delivery systems nanoparticles liposomes. consolidates recent findings on presents outlook future research clinical application, emphasizing promise optimizing pharmacotherapy.