Effects of L-carnitine on healing of Achilles tendon in rats

• DOI: 10.52312/jdrs.2023.853
• Publication Date: 2023-01-18T10:53:17Z
• Authors: Burak Kuşcu; Ökkeş Bilal; Fatih Doğar; Duran Topak; Kaan Gürbüz; Kadir İsmail Dere; Mikail Telek; Ali Aydın Karadeniz; Muhammed Seyithan...; Sezen Koçaslan
• Keywords: Tenotomy; Polydioxanone; Matrix metalloproteinase 9

In this experimental study, we aimed to analyze the effects of levocarnitine (L-carnitine) on tendon healing after surgical repair Achilles rupture in a rat model.The study included 40 Wistar Albino rats divided into four groups: Group 1, neither intervention nor substance applications were performed for tendons. other groups, right tendons cut using scalpel and repaired with modified Kessler-type technique 3/0 monofilament polydioxanone suture. 2, did not receive any additional treatment, except repair. 3, same volume similar 4 saline solution was administered intraperitoneally seven days. 4, each received 300 mg/kg L-carnitine At Week 6, all sacrificed. All used biomechanical tests histopathological evaluations. Biochemical analysis matrix metalloproteinase also blood specimens.There no significant differences among groups terms parameters. Although mean level low group, it reach statistical significance. A increase maximum force, tensile strength, strength 2-mm gap observed group.The parameters may indicate favorable by reducing 2 9. To improve healing, further investigation these markers is needed. Since cannot be clearly distinguished histopathologically, studies involving L-carnitine-induced are warranted.