Occupational exposure to organic solvents and risk of male breast cancer: a European multicenter case-control study

• DOI: 10.5271/sjweh.3717
• Publication Date: 2018-02-06T05:16:49Z
• Authors: Nasser Laouali; Corinne Pilorget; Diane Cyr; Monica Neri; Linda Kaerlev; Svend Sabroe; Giuseppe Gorini; Lorenzo Richiardi; Maria Morales-Suá...; Agustin Llopis-Go...; Wolfgang Ahrens; Karl-Heinz Jöckel; Noemia Afonso; Mikael Eriksson; Eriksson Merletti; Jørn Olsen; Elsebeth Lynge; Pascal Guénel
• Keywords: Male; Ethylene Glycol; european; BENZENE; trichloroethylene; Medizin; ethylene glycol; male breast cancer; jem; benzene; 0302 clinical medicine; Risk Factors; Surveys and Questionnaires; multicenter case-control study; POPULATION; Petroleum solvent; Incidence; OCCUPATIONAL EXPOSURE; JOB-EXPOSURE MATRIX; WOMEN; WORKERS; ETHYLENE GLYCOL; job-exposure matrix; Middle Aged; 3. Good health; Europe; Occupational Diseases; Occupational Diseases/chemically induced; Solvents/toxicity; UNESCO::CIENCIAS MÉDICAS ::Patología::Oncología; UNESCO::CIENCIAS MÉDICAS; organic solvent; petroleum solvent; Public aspects of medicine; RA1-1270; ORGANIC SOLVENT; Job-exposure matrix; PETROLEUM SOLVENT; Adult; Ethylene Glycol/toxicity; TRICHLOROETHYLENE; case-control study; ENDOCRINE-DISRUPTING CHEMICALS; 610; chlorinated solvent; Breast Neoplasms; Male/chemically induced; Trichloroethylene/toxicity; Europe/epidemiology; CHLORINATED SOLVENT; Breast Neoplasms, Male; 03 medical and health sciences; breast cancer; Alcoholic solvent; BREAST CANCER; Occupational Exposure; cancer; Humans; COHORT; CASE-CONTROL STUDY; Ethylene glycol; Benzene/toxicity; Aged; Retrospective Studies; ETHYLENE-GLYCOL ETHERS; MORTALITY; Occupational Exposure/adverse effects; EUROPEAN; OXIDE; Benzene; occupational exposure; Breast Neoplasms, Male/chemically induced; JEM; MALE BREAST CANCER; Trichloroethylene; Logistic Models; Chlorinated solvent; Case-Control Studies; alcoholic solvent; Solvents; [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie; ALCOHOLIC SOLVENT; MULTICENTER CASE-CONTROL STUDY

Objectives The etiology of male breast cancer (MBC) is largely unknown but a causal role exposure to organic solvents has been suggested. Previous studies on occupational risk factors were often restricted women who are frequently exposed lower levels and at frequency than men. We investigated the association between MBC petroleum oxygenated chlorinated in multicenter case-control study rare cancers Europe. Methods included 104 cases 1901 controls. Detailed lifetime work history was obtained during interviews, together with sociodemographic characteristics, medical lifestyle factors. Occupational exposures estimated from job-exposure matrix. Odds ratios (OR) their 95% confidence intervals (CI) calculated using unconditional logistic regression models. Results Lifetime cumulative trichloroethylene >23.9 ppm years associated an increased risk, compared non-exposure [OR (95% CI): 2.1 (1.2–4.0); P trend <0.01). This increase persisted when only that occurred ≥10 before diagnosis considered. In addition, possible for benzene ethylene glycol suggested, no exposure-response observed. Conclusions These findings add evidence among men professionally possibly or glycol. Further should be conducted populations high level confirm our results.