Gliomatosis Cerebri in Two Dogs

• DOI: 10.5326/jaaha-ms-5796
• Publication Date: 2012-07-29T00:52:47Z
• Authors: Brandon L. Plattner; Marc Kent; Brian Summers; Simon R. Platt; A. Courtenay Freeman; Uriel Blas-Machado; Jessie Clemans; Norman F. Cheville; David Garcia-Tapia
• Keywords: Cranial nerves

A 3.5 yr old Saint Bernard was evaluated for nonambulatory tetraparesis and cranial nerve dysfunction, a 7 rottweiler progressive paraparesis. Clinical signs of left-sided vestibular general proprioceptive ataxia VII dysfunction in the suggested lesion affecting brain stem. Signs consisted proprioceptive/upper motor neuron paraparesis, suggesting involving third thoracic (T3) to lumbar (L3) spinal cord segments. MRI normal Bernard, but an intra-axial T13-L2 segments observed rottweiler. In both dogs, central nervous system (CNS) contained neoplastic cells with features consistent gliomatosis cerebri (GC). were present medulla oblongata cervical cord. rottweiler, only Immunohistochemistry disclosed two distinct patterns CD18, nestin, vimentin staining. GC is rarely reported tumor CNS. Although typically involves cerebrum, clinical these dogs reflected caudal brainstem involvement.