Association of Pre-PCI Blood Pressure and No-Reflow in Patients with Acute ST-Elevation Coronary Infarction

• DOI: 10.5334/gh.1309
• Publication Date: 2024-03-04T13:04:16Z
• Authors: Xiaobo Li; Chen Yu; Li Lei; Xuewei Liu; Yejia Chen; Yutian Wang; ShiFeng Qiu; Jiancheng Xiu
• Keywords: 03 medical and health sciences; 0302 clinical medicine; stemi (st-elevation acute coronary infarction); dbp(diastolic blood pressure); RC666-701; noreflow; Diseases of the circulatory (Cardiovascular) system; Public aspects of medicine; RA1-1270; sbp(systolic blood pressure); Original Research

Background: Previous studies have established blood pressure (BP) as a pivotal factor influencing no-reflow following primary percutaneous coronary intervention (PCI) in patients with ST-elevation acute infarction (STEMI). However, no relevant study has been conducted to investigate the optimal range of BP associated lowest risk among STEMI so far. Therefore, our objective was evaluate association between pre-PCI and occurrence STEMI. Method: We included 1025 undergoing PCI. The categorized into 20-mmHg increments. Logistic models were employed assess systolic (SBP) or diastolic (DBP). Three sensitivity analyses further confirm robustness no-reflow. Results: SBP DBP exhibited U-shaped curve No-reflow higher lower (<100 mmHg) (adjusted hazard ratio (OR) 3.64, 95% confidence interval (CI) 1.84,7.21; p < 0.001) (<60 (OR 3.28, CI 1.63,6.49; [reference: 120 ≤SBP <140; 80 ≤DBP <100 mmHg], respectively. Furthermore, (≥160 2.07, 1.27,3.36; = 0.003) (≥100 3.36, 2.07,5.46; 0.001), results consistent above findings. Conclusion: Maintaining within 140 mmHg 100 may be confer benefits