Correlation Between Apparent Diffusion Coefficient Value on MRI and Histopathologic WHO Grades of Neuroendocrine Tumors

• DOI: 10.5334/jbsr.1925
• Publication Date: 2020-01-30T10:49:50Z
• Authors: Wouter Mebis; Annemiek Snoeckx; Bob Corthouts; Haroun El Addouli; Simon Nicolay; Astrid Van Hoyweghen; Maarten Spinhoven; Bart Op de Beeck
• Keywords: Value (mathematics)

The correlation of diffusion-weighted MRI and tumor aggressiveness has been established for different types, which leads to the question if it could also apply neuroendocrine tumors (NET).To investigate possible between apparent diffusion coefficient (ADC) value on magnetic resonance imaging (MRI) histopathologic WHO-grades NET.Electronic patient records from patients presented at multidisciplinary neuro-endocrine board November 2017 April 2019 were retrospectively reviewed. Patients with both available MR (primary or metastasis) known WHO grade included (n = 47). Average minimum ADC values (avgADC; minADC) measured by drawing a freehand ROI excluding only outermost border lesion. largest axial size tumor) most clearly delineated lesion (metastasis) was used.Forty seven met inclusion criteria (mean age 59 ± 12 SD; 24F/23M). Twenty one (45%) diagnosed G1 tumor, 17 seventeen G2 (36%) nine G3 (19%) tumor. eight primary 19 metastases measured. A significant difference found low-grade (G1+G2) high-grade (G3) (Mann-Whitney; avgADC: p < 0,001; minADC: 0,001). There moderate negative WHO-grade avgADC/minADC (Spearman; -0,606; 95% CI [-0,773; -0,384]; -0,581; [-0.759; -0.353]).Our data show in average low high NET. value.