Radiation-Induced Lung Injury on PET/CT: Analysis of FDG Uptake Response within Specific Isodose Regions of Irradiation in Non-small Cell Lung Cancer Patients

• DOI: 10.5336/medsci.2010-22044
• Publication Date: 2011-10-12T12:43:39Z
• Authors: Feyza ŞEN; A. Tayyar AKPINAR; Lutfi ÖZKAN; İlker ERCAN; Ümit OĞUR; Yasemin ÖZTÜRK DE...; Sema GÖZCÜ
• Keywords: Standardized uptake value; Fluorodeoxyglucose; PET-CT

Objective: Inflammatory response associated with radiation-induced lung injury (RILI) results in an increased 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT). In this study, we aimed to analyze the degree of FDG within specific isodose regions (IR) irradiated using standardized value (SUV) measurements, and correlate posttreatment radiotherapy (RT) dose parameters, patient characteristics imaging time interval after RT completion. Material Methods: Data from 30 patients non-small cell cancer (NSCLC) who underwent PET/CT at least 12 weeks (72-668 days) completion were evaluated. each patient, side-by-side visual registration treatment planning CT slices including IR curves corresponding was performed. Using SUV levels analyzed IRs lung. The statistical difference between SUVmax determined. tested for correlation IRs. Results: mean that received 2000-4000cGy 1.51 ± 0.66 (mean SD) (min-max: 0.69-2.84), 4000-6000cGy 2.67 1.16 0.71-6.0), >6000Gy 3.55 1.09 1.2-5.72). We found statistically significant differences values all (SUV2000 vs. SUV4000, p= 0.001; SUV2000 vs.6000, 0.002; SUV4000 6000, 0.001). No other variables. Conclusion: findings study showed that, although some overlap occurs IRs, radiation-related parenchymal gets higher increasing levels. Persistent high may be observed radiation fibrosis areas even several months RT.