Neuropsychiatric Features of a Cohort of Patients with Systemic Lupus Erythematosus

• DOI: 10.5402/2012/989218
• Publication Date: 2012-11-20T21:01:39Z
• Authors: Maria Francisca M...; Isabel Lúcio; Céu Santos; Maria Manuel Campos; Nuno Riso; Manuel Vaz Riscado
• Keywords: 03 medical and health sciences; 0302 clinical medicine; HCC IMU; Clinical Study; HSJ NRAD; Lupus, Erythematosus, Systemic; HCC MED; Retrospective Studies; 3. Good health

In order to establish if neuropsychiatric systemic lupus erythematosus (NPSLE) can be identified by any characteristic other than those used diagnose the (NP) disease itself, we retrospectively reviewed 98 (SLE) patients followed over a mean period of 10 years. NPSLE was in 22 patients. Stroke and generalized seizures were most frequent NP manifestations. The non-NPSLE groups similar with regard demographic characteristics, ACR criteria, serum autoantibodies, frequency hypertension hypercholesterolemia. Of note, compared group, associated higher smoking (78 versus 26%), organ damage (73 34%), cumulative mortality rate (14 7%). series further analysed according presence antiphospholipid syndrome (APS). Significantly, interval between onset SLE diagnosis shorter APS − (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mn>0.3</mml:mn><mml:mo>±</mml:mo><mml:mn>1</mml:mn></mml:mrow></mml:math> years) + id="M2"><mml:mrow><mml:mn>5</mml:mn><mml:mo>±</mml:mo><mml:mn>7</mml:mn></mml:mrow></mml:math> groups. Recurrence and/or persistence events only documented group. Overall highest inadequate anticoagulation control, identifying an aspect that requires improved vigilance development novel therapeutic modalities.