Development and validation of pharmaceutical oral formulation of bilayer tablet of sustained release and immediate release of gliclazide

• DOI: 10.54085/ap.2023.12.2.114
• Publication Date: 2024-01-18T06:32:51Z
• Authors: Awdhut D. Pimpale; Priyanka S. Waghmare; Pravin B. Suruse; Neha P. Rumale; Mrunal T. Deshmukh
• Keywords: Gliclazide; Immediate release

The purpose of this study was to create a gliclazide bilayer tablet with bimodal drug release.The main objective is investigate the potential xanthan gum as bioadhesive, sustained-release layer.Here, used cross-carmellose, cross-povidone, and SSG.Swollen volume outside bioadhesion, dissolution kinetics, water absorption, in vitro release were checked.A non-Ficki diffusion-regulated mechanism kinetics after first burst, leading Higuchi model (R 2 = 0.9913).All 32 full factorial designs considered current study.The optimal disintegration time for direct compression technique utilizing cross-povidone resulted immediate formulation (IR3).According testing results, 13 seconds.In formulation, kind polymers coupled amount polymer substituted sodium cross-carmellose independent variables.It possible adequately incorporate mucilage into tablets while preserving high adhesiveness sustained by replacing only 20% natural mucilage, such gum, sodium.