Structure-activity Relationships of Antioxidant Activity in vitro about Flavonoids Isolated from Pyrethrum Tatsienense

• DOI: 10.5455/jice.20140619030232
• Publication Date: 2014-07-04T06:06:41Z
• Authors: ChaoZhan Lin; ChenChen Zhu; Min Hu; AiZhi Wu; Bairu Zerendawa; Kangsa Suolangqimei
• Keywords: Hydroxyl radical; IC50; Structure–activity relationship

Antioxidant activity is one of the important indexes for estimating medicinal value traditional Chinese medicine. The aim this study to investigate antioxidant 11 flavonoids mainly revealing luteolin as mother nucleus isolated from Pyrethrum tatsienense.The was measured in vitro using classical 1,1-diphenyl-2-picrylhydrazyl removal method. percentages scavenging were analyzed by taking choice a-tocopherol positive drugs, and plotted against sample concentration obtain IC50 values.Ten containing phenolic hydroxyl groups have different levels activity. depends on numbers substitutional positions hydroxyls B ring. When C-3', 4' ring are replaced groups, improved remarkably. Phenolic A contribute some because electrophilic effect C ring, methoxyl glycosyl a little activity.Structure-activity relationships about P. tatsienense concluded, which will be beneficial deep understanding pharmacological functions Tibetan medicine vivo point antioxidation.