Protecting mechanism of Swietenia macrophylla ethanol extract nanoparticle on Streptozotocin induced renal damage in rat

• DOI: 10.5455/ovj.2023.v13.i12.12
• Publication Date: 2024-01-03T21:58:16Z
• Authors: Rochmah Kurnijasanti; Giftania Wardani; Mohammad Mustafa; Sri Sudjarwo
• Keywords: Swietenia macrophylla; Malondialdehyde

Background: Hyperglycemia increases Reactive Oxygen Species (ROS), which contributes to diabetic complications such as kidney cell damage. Antioxidant administration could inhibit ROS and damage commonly seen in hyperglycemia. Aim: We want demonstrate that the antioxidant properties of Swietenia macrophylla ethanol extract nanoparticles can prevent brought on by streptozotozine (STZ) current investigation. Methods: This study employs high-energy ball milling produce from extract. Additionally, dynamic light scattering (DLS) is utilized characterize nanoparticle sizes Five groups, each consisting eight rats, were formed 40 animals. Control rats received distilled water, administered streptozotocin injections, while given orally injection. After trial, blood a rat was drawn intracardially check levels urea nitrogen (BUN) creatinine. The superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA) then assessed tissue samples. Histological alterations evaluated section Results: A Dynamic Light Scattering analysis estimated size be about 91.50 ± 23.06 nm. BUN creatinine significantly raised after STZ treatment. decreased SOD GPx raising MDA (p< 0.05). caused increased Creatinine normal (P<0.05), indicating prevented STZ-induced liver raise lowering (p < These actions are thought have histological (degeneration necrosis) rats. Conclusion: According these results, anti-oxidative stress make them potentially effective nephroprotective therapies for