Effects of upadacitinib and PD29 on oxidative damage and inflammation in bleomycin-induced scleroderma model kidney tissues

• DOI: 10.5472/marumj.1381649
• Publication Date: 2023-10-26T11:10:04Z
• Authors: Ayşe Koçak; Meliha Koldemir G...; Güllü Kaymak; Elif Aydın
• Keywords: Malondialdehyde

Objective: Scleroderma (SSc) is a rare autoimmune tissue disease. There currently no effective treatment for SSc. The aim of this study was to investigate the antioxidant and anti-inflammatory effects upadacitinib PD29 on total oxidant status (TOS), (TAS), malondialdehyde (MDA), catalase (CAT), glutathione (GSH) peroxidase levels, interleukin-6 (IL-6) interleukin-13 ( IL-13) in kidney tissues an experimental SSc model. Materials Methods: design established with five groups eight mice: Control, bleomycin (BLM) (5 μg/kg), BLM + (3mg/kg), mg/kg) group. administered subcutaneously once day 21 days. (gavage) were injected Renal collected at end experiment. TOS, TAS, MDA, CAT, GSH IL-6 IL-13 gene expressions evaluated. Results: Upadacitinib affected TOS. MDA levels decreased, GSH, TAS increased. Also, decreased inflammation via cytokines. Conclusion: may have therapeutic roles renal crisis.