The effects of early exercise in traumatic brain-injured rats with changes in motor ability, brain tissue, and biomarkers

• DOI: 10.5483/bmbrep.2022.55.10.097
• Publication Date: 2022-10-31T06:26:06Z
• Authors: Chung Kwon Kim; Jee Soo Park; Eunji Kim; Min-Kyun Oh; Yong-Taek Lee; Kyung Jae Yoon; Kyeung Min Joo; Kyunghoon Lee; Young Sook Park
• Keywords: Brain tissue

Traumatic brain injury (TBI) is damage which caused by the impact of external mechanical forces. TBI can lead to temporary or permanent impairment physical and cognitive abilities, resulting in abnormal behavior. We recently observed that a single session early exercise animals with improved their behavioral performance absence other abnormalities. In present study, we investigated therapeutic effects continuous during stages rats. found low-intensity early-stage improves locomotion recovery animal models; however, it does not significantly enhance short-term memory capabilities. Moreover, only reduces protein expression cerebral damage-related markers, such as Glial Fibrillary Acid Protein (GFAP), Neuron-Specific Enolase (NSE), S100β, Gene Products 9.5 (PGP9.5), Heat Shock 70 (HSP70), but also decreases apoptosis-related BAX cleaved caspase 3. Furthermore, training microglia activation inflammatory cytokines serum, CCL20, IL-13, IL-1α, IL-1β. These findings thus demonstrate therapy for may be an effective strategy improving physiological function, serum levels are useful biomarkers predicition effectiveness therapy.[BMB Reports 2022; 55(10): 506-511].