In vivo Genotoxicity of Silver Nanoparticles after 90-day Silver Nanoparticle Inhalation Exposure

• DOI: 10.5491/shaw.2011.2.1.34
• Publication Date: 2011-04-27T05:41:49Z
• Authors: Jin Sik Kim; Jae Hyuck Sung; Jun Ho Ji; Kyung Seuk Song; Ji Hyun Lee; Chang Soo Kang; Il Je Yu
• Keywords: Silver nanoparticle; Inhalation exposure

Objectives: The antimicrobial activity of silver nanoparticles has resulted in their widespread use many consumer products. Yet, despite advantages, it is also important to determine whether may represent a hazard the environment and human health. Methods: Thus, evaluate genotoxic potential nanoparticles, vivo genotoxicity testing (OECD 474, micronuclei test) was conducted after exposing male female Sprague-Dawley rats by inhalation for 90 days according OECD test guideline 413 (Subchronic Inhalation Toxicity: Day Study) with good laboratory practice system. were exposed (18 nm diameter) at concentrations 0.7 × 106 particles/cm3 (low dose), 1.4 (middle 2.9 (high dose) 6 hr/day an chamber days. killed 24 hr last administration, then femurs removed bone marrow collected evaluated micronucleus induction. Results: There no statistically significant differences micronucleated polychromatic erythrocytes or ratio among total nanoparticle exposure when compared control. Conclusion: present results suggest that does not induce genetic toxicity rat vivo.