Evaluation of Brine shrimp lethality and Antimicrobial activity of Azadirachta indica leaf extract on some drug resistance bacteria in Bangladesh

• DOI: 10.5530/pj.2011.20.13
• Publication Date: 2011-03-25T00:25:08Z
• Authors: Abdullah-Al-Emran; S.M Shahed; Farzana Ahmed; Sajal Kumar Saha; Sreedam Chandra Das; Sitesh Chandra Ba...
• Keywords: Azadirachta; Lethality; Brine shrimp

Abstract Azadirachta indica (Neem) is very useful traditional medicinal plant in the subcontinent. Each part of tree has some properties. In this present studies bioactivity and antimicrobial activity leaf extract was evaluated. For bioactivity, Brine shrimp lethality test done for A. ethanolic determined LC50 37.15 μg/ml indicating that prepared rich bioactive compounds. Ethanolic also used to evaluate antibacterial exhibited significant against tested bacterial strain. However, inhibitory concentration organism dependent. Gram-positive bacteria were more sensitive compare Gram-negative bacteria. All showed sensitivity at higher (7mg/ml) but multi drug resistant Klebsiella pneumoniae even low (2mg/ml). Further, results depict extracts could be as a potential source agents strains tested.