Supplementation of Caesalpinia Sappan L. Extract to Increase Superoxide Dismutase Activity and Suppress Malondialdehyde Levels in Sprague Dawley Exposed to Inhaled Formaldehyde

• DOI: 10.5530/pj.2023.15.147
• Publication Date: 2023-11-03T10:00:20Z
• Authors: Ulfa Nurullita; Neni Susilaningsih; Ari Suwondo; Suhartono Suharto...; Kisdjamiatun Retn...
• Keywords: Malondialdehyde; Dismutase

Introduction: It is not yet known how Caesalpinia sappan L. extract (CSE) affects the activity of SOD and MDA levels in rats exposed to inhaled formaldehyde. Method: This true experimental study vivo uses a randomized post-test-only control group design. The subjects were male Sprague Dawley, 2-4 months old, weight 200-300 grams, total 30 heads divided into 6 groups. treatment was given CSE at doses 0, 100, 400, 1000 g/kg BW for 28 days, formaldehyde 2 weeks, 8 hours/day. measured using ELISA kit. Statistical analysis used Kruskall Wallis, Mann Whitney, rank spearman tests with α= 5%. Results: highest average lowest negative group. positive difference between groups p-value = 0.016, while has 0.915. relationship 0.02 (correlation coefficient -0.422). Conclusion: can increase superoxide dismutase enzymes but been able suppress malondialdehyde levels. There an association increased enzyme decreased Dawley