Human Cholestryl Ester Transfer Protein (TaqIB) Polymorphism among Filipinos with Cardiovascular Risk Factors

• DOI: 10.5551/jat.14.116
• Publication Date: 2011-06-16T13:45:32Z
• Authors: Rody G Sy; Eva Maria C Cutio...; Felix Eduardo R P...; Ronald S Santos; Francis Ruel B Ge...; Rogelio V Tangco
• Keywords: Cholesterylester transfer protein; Dyslipidemia; Lipid Profile

HDL-C has emerged as an important independent predictor of cardiovascular disease. The FNRI-HDL and NNHes Study Group in the Philippines reported that there was a high prevalence low HDL among Filipinos. Most cases are associated with secondary causes like Metabolic Syndrome. A primary cause reduced such increase Cholesteryl Ester Transfer Protein activity been identified.1. To determine phenotype frequency (TaqIB) polymorphism Filipinos risk factors. 2. association TaqIB levels factors.Cross-sectional Study.University Philippines-Philippine General Hospital.Descriptive statistics, Chi square test Fisher's correlation using Stata version 6.Fifty patients were included this pilot study examined respect to genotype, lipid profiles, blood sugar other Polymerase Chain Reaction (PCR), Restriction Fragment Length Polymorphism (RFLP) Agarose Gel Electrophoresis techniques used CETP Polymorphism.Out 50 patients, 66% females 34% males mean age 55 y/o BMI 27 kg/m(2). following factors identified: hypertension (92%), dyslipidemia (88%), obesity (68%), smoking (50%), diabetes mellitus type 2 (18%) family history premature CAD (14%). genotype frequencies B1B1; B1B2; B2B2 40%; 50% 10% respectively. B1B1 homozygote lower (45.35 +/- 8.82 mg/dL) compared B1B2 (48.96 10.10 (48.99 10.13 mg/dL)).Cholesteryl Polymorphisms exist (40%), (50%) (10%). is more common than HDL-C.