Impact of the Serum Uric Acid Level on Subclinical Atherosclerosis in Middle-aged and Elderly Chinese

• DOI: 10.5551/jat.26260
• Publication Date: 2015-02-16T22:05:07Z
• Authors: Ying Chen; Baihui Xu; Wanwan Sun; Jichao Sun; Tiange Wang; Yu Xu; Min Xu; Jieli Lu; Xiaoying Li; Yufang Bi; Weiqing Wang; Guang Ning
• Keywords: Quartile; Cross-sectional study

Aim: The carotid intima-media thickness (CIMT) is now validated as a sensitive marker of atherosclerosis and directly associated with an increased risk cardiovascular disease. Considering that the independent association between serum uric acid level CIMT remains controversial due to complex interrelationship other known factors, further studies are needed. aim present study explore in general Chinese population determine whether differs according varied metabolic status.Methods: was cross-sectional design. A total 10,281 community-based participants 40 years age or older from Shanghai, China were included current analysis. All underwent detailed questionnaire interview, anthropometric measurements ultrasonography assess CIMT. Blood urine samples collected for biochemical measurements.Results: levels positively obesity- diabetes-related parameters In logistic regression model controlling potential confounders, compared first quartile level, those fourth had higher odds elevated both men (odds ratio [OR]=1.37; 95% confidence interval [CI]=1.07-1.75) women (OR=1.48; CI=1.12-1.94). subgroup analyses revealed persisted regardless diuretic use hypertension, diabetes mellitus chronic kidney disease status. However, disappeared patients who consumed alcohol premenopausal women.Conclusions: middle-aged elderly subjects, determinants